• Piscine Orthoreovirus (PRV)-3, but Not PRV-2, Cross-Protects against PRV-1 and Heart and Skeletal Muscle Inflammation in Atlantic Salmon 

      Malik, Muhammad Salman; Teige, Lena Hammerlund; Braaen, Stine; Olsen, Anne Berit; Nordberg, Monica; Amundsen, Marit; Kannimuthu, Dhamotharan; Svenning, Steingrim; Edholm, Eva-Stina Isabella; Takano, Tomokazu; Jørgensen, Jorunn; Wessel, Øystein; Rimstad, Espen; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-06)
      Heart and skeletal muscle inflammation (HSMI), caused by infection with Piscine orthoreovirus-1 (PRV-1), is a common disease in farmed Atlantic salmon (Salmo salar). Both an inactivated whole virus vaccine and a DNA vaccine have previously been tested experimentally against HSMI and demonstrated to give partial but not full protection. To understand the mechanisms involved in protection against HSMI ...
    • Specific antibody responses (IgM) against Piscine orthoreovirus (PRV) in Atlantic salmon (Salmo salar), measured in a multiplexed magnetic bead-based system 

      Nordberg, Monica (Master thesis; Mastergradsoppgave, 2021-05-16)
      Piscine orthoreovirus (PRV) causes heart- and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). HSMI causes significant economic losses to the salmon aquaculture industry, and there is currently no vaccine available. In the trial this master thesis is based on, Atlantic salmon were injected with PRV-1, PRV-2, PRV-3 and inactivated PRV-1 to explore cross immunity ...